Citrate is a critical metabolite required to support both mitochondrial bioenergetics and cytosolic macromolecular synthesis. When cells proliferate under normoxic conditions, glucose provides the ...
Chronic Physical Effects and Health Care Utilization in Long-Term Ovarian Germ Cell Tumor Survivors: A Gynecologic Oncology Group Study Patients were selected according to the following criteria: ...
Figure 1: Identification of BCL-2 as synthetic lethal to mutant IDH1. Figure 3: ABT-199 targets IDH1/2 mutant primary human AML cells. Figure 4: (R)-2-HG–mediated inhibition of cytochrome c oxidase ...
Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma The triplet regimens were well tolerated with low early mortality (n = 1 [2 ...
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