Nature

Bim and Bmf in tissue homeostasis and malignant disease

In 1998 O'Connor and colleagues described a BH3-only protein discovered while screening a bacteriophage λ cDNA expression library using recombinant Bcl2 as bait. The protein was termed Bim (Bcl-2 ...
Nature

BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals

Members of the BCL-2 family of proteins are key regulators of the intrinsic, or mitochondrial, apoptotic pathway. The BCL-2 family can be subdivided into three main functional classes based primarily ...
ascopubs.org

Evaluation of pro-apoptotic BIM gene loss of function on lapatinib efficacy in patients with metastatic breast cancer (MBC) and in HER2-amplified cell lines.

A nonrandomized phase II study of dose-dense paclitaxel and cyclophosphamide (PC) in early-stage breast cancer (EBC). This is an ASCO Meeting Abstract from the 2014 ASCO Annual Meeting I. This ...